Recently, Professor Xi Rimo and Associate Professor Meng Meng of the School of Pharmacy of Nankai University published a research paper entitled "A Tumor Targeting Near Infrared Heptamethine Cyanine Photosensitizer with Twisted Molecular Structure for Enhanced Imaging Guided Cancer Phototherapy" in J. Am. Chem. Soc., an international famous academic journal. The research team designed and synthesized a tumor targeted near-infrared photosensitizer T780T: introducing a twisted structure of tetraphenylethylene (TPE) between two molecular cyanine photosensitizers IR780 to improve its photothermal conversion efficiency and photothermal stability. The molecule T780T can be self-assembled into uniform nano aggregates in the aqueous phase. After the tumor bearing mice were injected into the tail vein, the T780T aggregates showed significant tumor accumulation effect. The treatment method of once administration and twice laser irradiation realized more significant tumor inhibition effect.
Download: https://pubs.acs.org/doi/10.1021/jacs.1c09155
